Ungraded products supplied by spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use. Nmethylnnitrosourea is a member of the class of nnitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups. Files are available under licenses specified on their description page. Acute shortterm exposure ton nitroso n methylurea in humans causes dermatitis. Tandem mass spectrometry data independently generated by scripps center for metabolomics is available to view or download in pdf. Liver cancer is one of the commonest forms of cancer jing, et al. Nitrosourea is both the name of a molecule, and a class of compounds that include a nitroso rno group and a urea. Urea standard safety data sheet supersedes revision. Buy nnitrosotris 2chloroethylurea cas 69115, a biochemical for proteomics research, from santa cruz. Also incompatible with water and nucleophilic reagents. Nmethylnnitrosourea is a nitrosourea compound with alkylating, carcinogenic, and mutagenic properties. Spectrum chemical manufactures and distributes fine chemicals with quality you can count on including those with cas number 684935, whether you call it nnitrosonmethylurea or nmethylnnitrosourea you can be assured the products offered by spectrum, meet or exceed the grade requirements or specifications for each individual product. Yes, nnitrosonmethylurea mnu is extremely hazardous. Special hazards arising from the substance or mixture specific hazards none known.
Sds of nnitrosonmethylurea, safety data sheets, cas 684935. Epa has classified n nitrosonmethylurea as a group b2, probable human carcinogen. Alkaline hydrolysis produces a highly toxic, irritating and explosive gas. Nnitrosonmethylethylamine casrn 10595956 iris us epa. N nitrosonmethylurea appears as pale yellow crystals or light yellow moist powder.
Get medical attention immediately if symptoms occur. It is incompatible with sodium nitrite, gallium perchlorate, strong oxidizing agents permanganate, dichromate, nitrate. N nitroso n methylurea appears as pale yellow crystals or light yellow moist powder. This fact sheet is a summary source of information of all. Nmethylnnitrosourea is a member of the class of nnitrosoureas that is. Toxicological information information on the toxicological effects of this product have not been thoroughly studied. The main sources of information for this fact sheet are the.
It has a role as a carcinogenic agent, a mutagen, a teratogenic agent and an alkylating agent. Environmental factors comprising tobacco smoke and various nitrostable foods hotckiss, 1989 containing n methyl n nitroso urea mnu, a carcinogenic nitroso compound aucher, 1982, are among the primary causes of liver cancer. Buy high quality n methyl n nitroso urea contains water 684935 from toronto research chemicals inc. In case of skin contact wash off with soap and plenty of water. Nnitroson methylurea appears as pale yellow crystals or light yellow moist powder. Nmethylnnitronnitrosoguanidine cameo chemicals noaa. N methyl n nitrosourea is a nitrosourea compound with alkylating, carcinogenic, and mutagenic properties. Material safety data sheet feed urea 46% page 8 of 9 issue date. California prop 65 warning signs for n nitroso n methylurea cas no. N1517 is packaged as an isopac so that the material does not need to weighed out. No commercial use of nnitroson methylurea is known.
Nnitrosonmethylurea68493 5 is incompatible with strong acids and bases. For more information about the substance, you may click one of the links below to take you to the relevant section. Nmu is an alkylating agent, and exhibits its toxicity by transferring its methyl group to nucleobases in nucleic acids, which can lead to at. In a single oral dose study in mice, 2,000 mgkg administered on day 10 of pregnancy was not teratogenic. Nnitrosonmethylurea 684935 hazard summary nnitrosonmethylurea has been studied in mutagenicity and genetics studies and for use as a cancer chemotherapy agent. Buy nnitroso akardite ii cas 1076199262, a biochemical for proteomics research, from santa cruz. California prop 65 warning signs for nnitrosonmethylurea cas no. Methyleneurea fertilizers article about methyleneurea.
I need to understand the step by step mechanism involved in the preparation of acetyl methyl urea from acetamide using bromine and. Explore information about air pollutants, contaminants and studies being done. All structured data from the file and property namespaces is available under the creative commons cc0 license. Buy high quality nmethylnnitroso urea contains water 684935 from toronto research chemicals inc. N nitroso n methylurea 684935 hazard summary n nitroso n methylurea has been studied in mutagenicity and genetics studies and for use as a cancer chemotherapy agent.
Nmethyl nnitroso urea induced altered dna structure. Reproductive tumorigenic effects transplacental tumorigenesis brain and coverings tumors reference. N nitroso n methylurea is incompatible with strong acids and bases. N methyl n nitrosourea is a member of the class of n nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.
These agents are different from the nitrogen mustards in that they alkylate through an sn 1 reaction, forming a highly reactive intermediate in the presence of n, o, and p nucleophiles in d. Nnitroson methylurea is incompatible with strong acids and bases. Methylurea revision date 26jan2018 urea, methyl 598505 95 4. Nmethylnnitrosourea 684935 suppliers buyersguidechem. We operates major facilities in north america, europe and the pacific rim, as well as facilities in china, japan and saudi arabia operated through joint ventures. Four chloroethyl nitrosoureas and one methyl nitrosourea are in clinical use. N nitroso n methylurea, abbreviated as nmu, is an alkylating agent and a precursor in the synthesis of diazomethane. It is a colorless crystalline powder with little toxicity. Urea material safety data sheet cas no 576 sdsmsds. Nmethyln nitronnitrosoguanidine will detonate under high impact. However, we make no warranty of merchantibility or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Nmu is the traditional precursor in the synthesis of diazomethane.
Nmu is an alkylating agent, and exhibits its toxicity by transferring its methyl group to nucleobases in nucleic acids. Ungraded products supplied by spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for. Nnitrosonmethylurea is incompatible with strong acids and bases. Acute shortterm exposure tonnitrosonmethylurea in humans causes dermatitis. Nnitroson methylurea nmu is a highly reliable carcinogen, mutagen, and teratogen. Recover any reusable product, taking care not to generate excess dust.
Nmu is an alkylating agent, and exhibits its toxicity by transferring its. Extreme high moderate low section 1 chemical product and company identification product name n methylurea statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910. Please see the following for information about the library and its accompanying search program. The in vitro enzymatic metabolism of nnitrosonmethylaniline was investigated using cytochromes p450 2b1 and p450 2b2, isolated from liver microsomes of rats pretreated with phenobarbital pb, reconstituted with nadphcytochrome p450 reductase and dilauroylphosphatidylcholine. They are produced by condensation of concentrated aqueous solutions of urea and formaldehyde in an acid medium. Acute shortterm exposure ton nitroson methylurea in humans causes dermatitis. The resultant product mainly methylene urea is filtered and pulverized.
Spectrum chemical manufactures and distributes fine chemicals with quality you can count on including those with cas number 684935, whether you call it n nitroso n methylurea or n methyl n nitrosourea you can be assured the products offered by spectrum, meet or exceed the grade requirements or specifications for each individual product. Environmental factors comprising tobacco smoke and various nitrostable foods hotckiss, 1989 containing nmethyl nnitroso urea mnu, a carcinogenic nitroso compound aucher, 1982, are. This structure is also available as a 2d mol file or as a computed 3d sd file the 3d structure may be viewed using java or javascript. N nitroso n methylaniline nma is an esophageal carcinogen in the rat. All mass spectra in this site plus many more are available from the nistepanih mass spectral library. Firstaid measures eye contact rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Nnitrosonmethylurea an overview sciencedirect topics. Methyleneurea fertilizers contain 3740 percent nitrogen 412 percent of which is watersoluble.
Nnitrosonmethylurea appears as pale yellow crystals or light yellow moist powder. Chemical proposition 65 nnitrosonmethylurea signs and labels. N nitroso n methylurea nmu is a highly reliable carcinogen, mutagen, and teratogen. Nnitroson methylurea 684935 hazard summary nnitroson methylurea has been studied in mutagenicity and genetics studies and for use as a cancer chemotherapy agent. Nmethylnnitroso urea suitable extinguishing media extinguish with alcoholresistant foam, carbon dioxide, dry powder or water fog. N methyl n nitroso urea suitable extinguishing media extinguish with alcoholresistant foam, carbon dioxide, dry powder or water fog. Sections i health hazard assessments for noncarcinogenic effects and. Nnitrosonmethylurea 684935 n2939 spectrum chemical. No commercial use of n nitroso n methylurea is known. Skin contact wash off immediately with plenty of water for at least 15 minutes.
Buy high quality nnitrosonmethylndodecylamine 55090443 from toronto research chemicals inc. This page was last edited on 31 august 2016, at 16. April 2006 significance was deemed questionable, since the lesion may occur in 100% of controls. Urea reacts with calcium hypochlorite or sodium hypochlorite to form the explosive nitrogen trichloride.
A sample has exploded when melted in a sealed capillary tube. Urea cas no 576 material safety data sheet sds msds. Nnitrosonmethylurea, abbreviated as nmu, is an alkylating agent and a precursor in the synthesis of diazomethane. Program and regulatory information about this substance, including links to epa applicationssystems, statuesregulations, or other sources that track or regulate this substance. While working with material safety data sheets msds, i found that manufacturers sometimes used obscure names for. We maintain independently or are partners of some production sites in europe, asia and south america. Any precautions that one can take to minimize handling the material would be advisable. Predicted data is generated using the us environmental protection agencys episuite. Use fireextinguishing media suitable for the surrounding fire. Nnitrosonmethylaniline nma is an esophageal carcinogen in the rat. This iris assessment for nnitrosonmethylethylamine consists of hazard identification and doseresponse assessment data and provides support for epa risk management decisions. Nnitrosonmethylurea nmu is a highly reliable carcinogen, mutagen, and teratogen. Extreme high moderate low section 1 chemical product and company identification product name nmethylurea statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910. This iris assessment for n nitroso n methylethylamine consists of hazard identification and doseresponse assessment data and provides support for epa risk management decisions.
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